By Günter Breithardt,Martin Borggrefe,John A. Camm,Mohammad Shenasa

The earlier 10 years have noticeable a amazing switch within the method of cardiac arrhythmias, from a place of self belief and a sense of future health approximately pharmacological remedy to a state of affairs within which there's now marked uncertainty and basic apprehension concerning the position of antiarrhythmic medicinal drugs. till particularly lately the existing suggestion in antiarrhythmic remedy was once that arrhythmias may be managed by way of medicinal drugs which slowed conduction or suppressed automaticity, ambitions good served by way of the sodium channel-blocking medicines and glycosides. Drug re­ seek was once dependent principally at the improvement of brokers mimicking these already to be had, yet with higher efficacy, fewer uncomfortable side effects or a extra beneficial phar­ macokinetic profile. the solid trial stands proud as a landmark within the evolution of arrhytmia deal with­ ment; hardly has a unmarried trial had the sort of profound effect not just on scientific prac­ tice, but additionally typically technique of these excited by the examine, improvement and rules of antiarrhythmic medications. the result of the solid trial, designed to redress the shortcomings of past trials which had did not exhibit the predicted development in mortality post-myocardial infarction with using category I brokers, are popular. the solid and forged II confirmed a rise in mor­ tality linked to the lively agent (encainide, flecainide or morizicine) com­ pared to placebo remedy. They firmly proven the capability possibility within the use of sophistication I drugs.

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Antiarrhythmic Drugs: Mechanisms of Antiarrhythmic and Proarrhythmic Actions by Günter Breithardt,Martin Borggrefe,John A. Camm,Mohammad Shenasa


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